GRP78-IN-3
Product Specifications
CAS Number
2707510-30-1
Target
HSP
Related Pathways
Metabolism|||Cytoskeletal Signaling
Purity
0.9949
Bioactivity
GRP78-IN-3, a potent small-molecule-competitive inhibitor of Hsp70 substrate binding and is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 ?M. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 ?M) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 ?M) .
Smiles
C(N[C@H](C(NC1=NC=CS1)=O)[C@H](C)C)(=O)C2=CC=3C(N2)=CC=CC3
Molecular Formula
C17H18N4O2S
Molecular Weight
342.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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