USP8-IN-3
Product Specifications
CAS Number
2477651-10-6
Target
DUB
Related Pathways
Ubiquitination|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Purity
0.9979
Bioactivity
USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 ?M against USP8D. USP8-IN-3 inhibited the proliferation of GH3 and H1957 cells with GI50 values of 37.03 ?M and 6.01 ?M, respectively. USP8-IN-3 is a potential compound for the treatment of cancer and viral infections.
Smiles
C(F)(F)(F)C1=NC(=CC=C1)N2CCC(NC(NC3=CC=C(N(=O)=O)C=C3)=S)CC2
Molecular Formula
C18H18F3N5O2S
Molecular Weight
425.43
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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UBE2Z, CT (UBE2Z, Ubiquitin-conjugating enzyme E2 Z, Uba6-specific E2 conjugating enzyme 1, Ubiquitin carrier protein Z, Ubiquitin-protein ligase Z) (MaxLight 405)
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