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USP8-IN-3

Product Specifications

CAS Number

2477651-10-6

Target

DUB

Related Pathways

Ubiquitination|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

Purity

0.9979

Bioactivity

USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 ?M against USP8D. USP8-IN-3 inhibited the proliferation of GH3 and H1957 cells with GI50 values of 37.03 ?M and 6.01 ?M, respectively. USP8-IN-3 is a potential compound for the treatment of cancer and viral infections.

Smiles

C(F)(F)(F)C1=NC(=CC=C1)N2CCC(NC(NC3=CC=C(N(=O)=O)C=C3)=S)CC2

Molecular Formula

C18H18F3N5O2S

Molecular Weight

425.43

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

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