TH1760
Product Specifications
CAS Number
2567914-01-4
Target
Others, DNA/RNA Synthesis, NUDIX hydrolase
Related Pathways
Metabolism, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Others
Purity
0.9731
Bioactivity
TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM) . TH1760 can sensitize cells to 6-thioguanine by increasing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 can enhance the anti-leukemia effect of thiopurine.
Smiles
S(=O)(=O)(C=1C=C2C(=CC1)NC(=O)O2)N3CCN(C(=O)C=4C=C5C(=CC4)NC=C5)CC3
Molecular Formula
C20H18N4O5S
Molecular Weight
426.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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