RBN-3143
Product Specifications
CAS Number
2360853-16-1
Target
PARP
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair
Purity
0.9952
Bioactivity
RBN-3143 is a potent inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM), which inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14 in cell lines, demonstrating research potential for lung inflammation.
Smiles
CC(=O)N1CCC(COc2cc(F)c3c(c2)nc(CSC2CCOCC2)[nH]c3=O)CC1
Molecular Formula
C22H28FN3O4S
Molecular Weight
449.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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