GSK215
Product Specifications
CAS Number
2743427-26-9
Target
PROTACs|||FAK
Related Pathways
Cytoskeletal Signaling|||PROTAC|||Tyrosine Kinase/Adaptors|||Angiogenesis
Purity
0.993
Bioactivity
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4), designed using the FAK inhibitor VS-4718 and a binder for the VHL E3 ligase, capable of inducing rapid and prolonged FAK degradation.
Smiles
CNC(=O)c1ccccc1Nc1cc(Nc2ccc(cc2OC)N2CCN(CC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)c3ccc(cc3)-c3scnc3C)C(C)(C)C)CC2)ncc1C(F)(F)F
Molecular Formula
C50H59F3N10O6S
Molecular Weight
985.13
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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