AT-533
Product Specifications
CAS Number
908112-37-8
Target
VEGFR, NF-κB, Akt, HSP, ERK, HIF/HIF Prolyl-Hydroxylase, FAK, HSV
Related Pathways
PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Metabolism, Microbiology/Virology, Tyrosine Kinase/Adaptors, NF-κB, Angiogenesis, MAPK, Chromatin/Epigenetic
Purity
0.9967
Bioactivity
AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, including Erk1/2, FAK, Akt/mTOR/p70S6K, . AT-533 inhibits the cell migration, invasion, and the tube formation of human umbilical vein endothelial cells (HUVECs) .
Smiles
Cc1nn(c2CC(C)(C)CC(=O)c12)-c1ccc(C(N)=O)c(N[C@H]2CC[C@H](O)CC2)c1
Molecular Formula
C23H30N4O3
Molecular Weight
410.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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