C004019
Product Specifications
CAS Number
2417159-57-8
Target
PROTACs|||Microtubule Associated
Related Pathways
PROTAC|||Cytoskeletal Signaling
Purity
0.9989
Bioactivity
C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C004019 is a candidate for AD and related tau protein diseases.
Smiles
N(CC(NCCOCCOCCOCC(N[C@H](C(=O)N1[C@@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@H](O)C1)C(C)(C)C)=O)=O)(C)C4=NC(=NC(NCCC5=CC=CS5)=N4)N6CCN(C(C)=O)CCC6
Molecular Formula
C49H70N12O9S2
Molecular Weight
1035.29
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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