BMS-903452
Product Specifications
CAS Number
1339944-47-6
Target
GPCR
Related Pathways
GPCR/G Protein, Endocrinology/Hormones
Purity
>99.99%
Bioactivity
BMS-903452 is a potent and selective GPR119 agonist with an EC50 of 14 nM, indicated for the treatment of acute and chronic rodent diabetes. GPR119 is mainly expressed in pancreatic b cells and gastrointestinal endocrine cells. BMS-903452 shows no significant inhibitory effect on 9 cytochrome P450 enzymes (IC50 > 40 μM), does not activate PXR (EC50 > 50 μM), and is not toxic to liver (HEPG2) cell lines.
Smiles
O=C1N(C=C(Cl)C(OC2CCN(CC2)C=3N=CC(Cl)=CN3)=C1)C4=C(F)C=C(S(C)(=O)=O)C=C4
Molecular Formula
C21H19Cl2FN4O4S
Molecular Weight
513.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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