Pemetrexed disodium heptahydrate
Product Specifications
CAS Number
357166-29-1
Target
DNA/RNA Synthesis|||DHFR|||Autophagy|||Antifolate
Related Pathways
Autophagy|||Cell Cycle/Checkpoint|||Metabolism|||DNA Damage/DNA Repair
Purity
0.9978
Bioactivity
Pemetrexed disodium heptahydrate (LY231514) is an antifolate that inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinyl-adenosine 5'-monophosphate (GARMT) with K_i values of 1.3 nM, 7.2 nM, and 65 nM respectively. This inhibits the formation of precursor purine and pyrimidine nucleotides and cancer cell proliferation, making it suitable for research into pleural mesothelioma and non-small cell lung cancer (NSCLC) .
Smiles
O.O.O.O.O.O.O.[Na+].[Na+].Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)NC(CCC([O-])=O)C([O-])=O)c[nH]c2[nH]1
Molecular Formula
C20H33N5Na2O13
Molecular Weight
597.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GTR15352590 1 Vial
Lentiviral human DMAC1 shRNA (UAS) - Lentiviral human DMAC1 shRNA (UAS, iRFP) (100)
Ask
View Details ![Mouse Monoclonal GADD45G Antibody (OTI2F12) [Alexa Fluor 750]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
NBP2-71646AF750 0.1 mL
Mouse Monoclonal GADD45G Antibody (OTI2F12) [Alexa Fluor 750]
Ask
View Details