Menin-MLL inhibitor 21
Product Specifications
CAS Number
2448172-22-1
Target
Histone Methyltransferase, Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Purity
0.9995
Bioactivity
Menin-mll inhibitor 21 is a selective, oral and irreversible Menin inhibitor. Menin-MLL inhibitor 21 promotes selective proliferation of β cells and improvement of β cell function in human islet cultures in vitro. Menin-MLL inhibitor 21 enhances glycemic control in animal models of diabetes. Menin-MLL inhibitor 21 induced a dose-dependent increase in insulin secretion that was augmented by a GLP-1 receptor agonist (RA) .
Smiles
N(C(=O)C1=CC(CN2C[C@H](NC(C=C)=O)CCC2)=CC=N1)C3=CC=C(C4=CC5=C(N=CN=C5N4)N6CCOCC6)C=C3
Molecular Formula
C31H34N8O3
Molecular Weight
566.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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