JI6
Product Specifications
CAS Number
856436-16-3
Target
JAK, FLT, c-Kit
Related Pathways
Chromatin/Epigenetic, Angiogenesis, JAK/STAT signaling, Stem Cells, Tyrosine Kinase/Adaptors
Purity
0.9864
Bioactivity
JI6 (JAK3 Inhibitor VI) is a potent, selective and orally active FLT3 inhibitor. JI6 exhibits IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 also inhibits c-Kit and JAK3, with IC50s of ∼500 and ∼250 nM, respectively. JI6 has research value in acute myeloid leukemia.
Smiles
CS(=O)(O)=O.O=C(/C1=C\C2=CC=CN2)NC(C=C3)=C1C=C3C4=CN=CC=C4
Molecular Formula
C19H17N3O4S
Molecular Weight
383.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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