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AZD0780

Product Specifications

CAS Number

2455427-91-3

Target

Others

Related Pathways

Others

Purity

0.9974

Bioactivity

AZD0780 (EX-A6975, PCSK9-IN-12) is an orally active PCSK9 inhibitor with high affinity for PCSK9 (Kd < 200 nM) . It binds to a specific pocket in the C-terminal domain of PCSK9 without affecting the PCSK9–LDLR interaction. AZD0780 blocks the lysosomal trafficking of the PCSK9–LDLR complex and prevents PCSK9-induced LDLR degradation, making it useful for studies related to hypercholesterolemia.

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FC(F)Oc1cnc(N[C@H]2CC[C@@H](C2)Nc2ccc(cn2)-n2ccccc2=O)nc1

Molecular Formula

C20H20F2N6O2

Molecular Weight

414.41

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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