AZD0780
Product Specifications
CAS Number
2455427-91-3
Target
Others
Related Pathways
Others
Purity
0.9974
Bioactivity
AZD0780 (EX-A6975, PCSK9-IN-12) is an orally active PCSK9 inhibitor with high affinity for PCSK9 (Kd < 200 nM) . It binds to a specific pocket in the C-terminal domain of PCSK9 without affecting the PCSK9–LDLR interaction. AZD0780 blocks the lysosomal trafficking of the PCSK9–LDLR complex and prevents PCSK9-induced LDLR degradation, making it useful for studies related to hypercholesterolemia.
Smiles
FC(F)Oc1cnc(N[C@H]2CC[C@@H](C2)Nc2ccc(cn2)-n2ccccc2=O)nc1
Molecular Formula
C20H20F2N6O2
Molecular Weight
414.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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