RUNX1/ETO tetramerization-IN-1
Product Specifications
CAS Number
88755-39-9
Target
Others
Related Pathways
Others
Bioactivity
RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor targeting NHR2 of RUNX1/ETO, effectively inhibiting tetramerization with an EC50 value of 0.25 μM. This compound restores gene expression down-regulated by RUNX1/ETO and demonstrates anti-leukemic activity by inhibiting proliferation of RUNX1/ETO-dependent SKNO-1 cells and reducing tumor growth in a mouse model [1] [2] [3].
Smiles
C(CC(=O)C=1C=C2C(=CC1)OCO2)(C(O)=O)C=3C=C4C(=CC3)OCO4
Molecular Formula
C18H14O7
Molecular Weight
342.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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