NBI-74330
Product Specifications
CAS Number
855527-92-3
Target
CXCR
Related Pathways
Autophagy, Immunology/Inflammation, GPCR/G Protein
Purity
0.9937
Bioactivity
NBI-74330 is a high-affinity CXCR3 antagonist that inhibits the binding of CXCR3 to its ligands CXCL10 and CXCL11, reduces the formation of atherosclerotic plaques in LDL receptor-deficient mice, and decreases the migration of CD4+ T cells and macrophages to the peritoneum.
Smiles
[C@@H](N(CC=1C=CC=NC1)C(CC2=CC(C(F)(F)F)=C(F)C=C2)=O)(C)C=3N(C(=O)C=4C(N3)=NC=CC4)C5=CC=C(OCC)C=C5
Molecular Formula
C32H27F4N5O3
Molecular Weight
605.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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