PROTAC (H-PGDS) -7
Product Specifications
CAS Number
2761281-50-7
Target
Prostaglandin Receptor, Molecular Glues, Others
Related Pathways
Immunology/Inflammation, Others, PROTAC, GPCR/G Protein
Bioactivity
PROTAC (H-PGDS) -7 is a selective and potent small molecule hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degradation agent that exhibits degradation activity in KU812 cells with a DC50 of 17.3 pM. It effectively inhibits prostaglandin D2 (PGD2) and is a candidate compound for the treatment of DMD and other H-PGDS-related diseases.
Smiles
O=C1C2=C(C=CC=C2C(=O)N1C3C(=O)NC(=O)CC3)N4CCN(C(=O)C5CCN(CC5)C6=CC=C(NC(=O)C=7C=NC(OC8=CC=CC=C8)=NC7)C=C6)CC4
Molecular Formula
C40H38N8O7
Molecular Weight
742.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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