Trimethylamine N-oxide
Product Specifications
CAS Number
1184-78-7
Target
TGF-beta/Smad, NOD-like Receptor (NLR), Reactive Oxygen Species
Related Pathways
Stem Cells, Immunology/Inflammation, NF-κB, Metabolism
Purity
0.98
Bioactivity
Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite derived from dietary choline, betaine, and carnitine. It induces inflammation by activating the ROS/NLRP3 inflammasome and promotes fibroblast differentiation through the activation of the TGF-β/Smad2 signaling pathway. TMAO is commonly used to induce cardiac fibrosis models.
Smiles
C[N+](C)(C)[O-]
Molecular Formula
C3H9NO
Molecular Weight
75.11
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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