Combretastatin A-1 phosphate tetrasodium

Combretastatin A-1 phosphate (OXi-4503) tetrasodium, a prodrug of Combretastatin A-1, is a tubulin-binding microtubule polymerization inhibitor targeting the colchicine-binding site. By inducing tubulin depolymerization, it inhibits the Wnt/β-catenin pathway and deactivates AKT, possessing both anti-tumor and anti-vascular properties.