Combretastatin A-1 phosphate tetrasodium
Product Specifications
CAS Number
288847-34-7
Target
Others|||Microtubule Associated|||Wnt/beta-catenin
Related Pathways
Stem Cells|||Others|||Cytoskeletal Signaling
Bioactivity
Combretastatin A-1 phosphate (OXi-4503) tetrasodium, a prodrug of Combretastatin A-1, is a tubulin-binding microtubule polymerization inhibitor targeting the colchicine-binding site. By inducing tubulin depolymerization, it inhibits the Wnt/?-catenin pathway and deactivates AKT, possessing both anti-tumor and anti-vascular properties.
Smiles
[Na].COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)c(OP(O)(O)=O)c1OP(O)(O)=O
Molecular Formula
C18H18Na4O12P2
Molecular Weight
580.24
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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