(S) -DI-87

(S) -DI-87 ((S) -TRE-515) is an isomer of DI-87.DI-87 is a novel and orally available dCK (deoxycytidine kinase) inhibitor with good in vitro activity and low protein binding.DI-87 binds to dCK and prevents the phosphorylation of deoxycytidine by dCK, resulting in a reduction in dNTP production and cell cycle arrest (especially in S phase) . When combined with thymidine, DI-87 significantly inhibits tumor growth.