(S) -DI-87
Product Specifications
CAS Number
2107280-58-8
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Purity
0.9942
Bioactivity
(S) -DI-87 ((S) -TRE-515) is an isomer of DI-87.DI-87 is a novel and orally available dCK (deoxycytidine kinase) inhibitor with good in vitro activity and low protein binding.DI-87 binds to dCK and prevents the phosphorylation of deoxycytidine by dCK, resulting in a reduction in dNTP production and cell cycle arrest (especially in S phase) . When combined with thymidine, DI-87 significantly inhibits tumor growth.
Smiles
[C@H](SC=1N=C(N)C=C(N)N1)(C)C=2N=C(SC2C)C3=CC(OCCN4CCOCC4)=C(OC)C=C3
Molecular Formula
C23H30N6O3S2
Molecular Weight
502.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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