4,9-Anhydrotetrodotoxin
Product Specifications
CAS Number
13072-89-4
Target
Others, Sodium Channel
Related Pathways
Others, Membrane transporter/Ion channel
Bioactivity
4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes) . [1][2][3] It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 µM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.[1]
Smiles
O[C@H]1[C@]23[C@@]4([C@@]5([C@](CO)(O)[C@]1(O[C@](O)([C@]2(O[C@@]4(N=C(N)N3)[H])[H])O5)[H])[H])[H]
Molecular Formula
C11H15N3O7
Molecular Weight
301.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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