D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)
Product Specifications
Target
Calcium Channel|||Others
Related Pathways
Membrane transporter/Ion channel|||Others|||Metabolism
Bioactivity
D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins (1,4,5,6) -P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins (1,4,5,6) -P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.[1] D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) (Ins (1,4,5,6) -P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins (1,4,5,6) -P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella. Ins (1,4,5,6) -P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway. Ins (1,4,5,6) -P4 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins (1,4,5) -P3 at initiating Ca2+ release when injected into Xenopus oocytes.[2]
Smiles
[Na].O[C@H]1[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O
Molecular Formula
C6H12Na4O18P4
Molecular Weight
588
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/3C59D9F7-6E96-4115-98FE-AD01D9BE3869/T35933
CAS Number
157542-47-7
Available Sizes
Curated Selection
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