D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)

D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins (1,4,5,6) -P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins (1,4,5,6) -P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.[1] D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) (Ins (1,4,5,6) -P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins (1,4,5,6) -P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella. Ins (1,4,5,6) -P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway. Ins (1,4,5,6) -P4 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins (1,4,5) -P3 at initiating Ca2+ release when injected into Xenopus oocytes.[2]