Semapimod tetrahydrochloride
Product Specifications
CAS Number
164301-51-3
Target
MAPK, p38 MAPK, TLR, Interleukin, TNF
Related Pathways
Immunology/Inflammation, MAPK, Apoptosis
Purity
0.998
Bioactivity
Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor that interferes with macrophage and microglia function. Sematimod tetrahydrochloride inhibits TLR4 signaling, TNF-α, IL-1β, and IL-6, and is used in the study of Crohn's disease and other inflammatory conditions.
Smiles
Cl.Cl.Cl.Cl.C\C(=N/NC(N)=N)c1cc(NC(=O)CCCCCCCCC(=O)Nc2cc(cc(c2)C(\C)=N\NC(N)=N)C(\C)=N\NC(N)=N)cc(c1)C(\C)=N\NC(N)=N
Molecular Formula
C34H56Cl4N18O2
Molecular Weight
890.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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