Otaplimastat HCl
Product Specifications
CAS Number
1176758-02-3
Target
MMP, NMDAR
Related Pathways
Proteases/Proteasome, Neuroscience
Purity
1
Bioactivity
Otaplimastat HCl is a matrix metalloproteinase (MMP) inhibitor that blocks NMDA receptor-mediated excitotoxicity competitively and exhibits antioxidant activity, In oxygen-glucose-deprived endothelial cells, otaplimastat suppressed the activity rather than protein expression of MMPs by restoring the level of tissue inhibitor of metalloproteinase (TIMP) suppressed in ischemia, and consequently reduced vascular permeation. serving as a tool for research into brain ischemic injury and neuroprotection.
Smiles
Cl.O=C1NC=2C=CC=CC2C(=O)N1CCCNCCCCN(C(=O)C)CCCN3C(=O)NC=4C=CC=CC4C3=O
Molecular Formula
C28H35ClN6O5
Molecular Weight
571.07
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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