Trimetazidine
Product Specifications
CAS Number
5011-34-7
Target
Others, Mitochondrial Metabolism, Antioxidant, Autophagy
Related Pathways
Autophagy, Others, Metabolism, Oxidation-Reduction
Purity
0.999
Bioactivity
Trimetazidine is a non-haemodynamic antianginal agent that selectively inhibits the mitochondrial enzyme 3-ketoacyl coenzyme A thiolase (LC 3-KAT), thereby preventing β-oxidation of free fatty acids, with an IC50 value of 75 nM. Trimetazidine prevents ischaemia-reperfusion injury by altering cardiac metabolism, exhibiting antioxidant and anti-ischaemic effects.
Smiles
COc1ccc(CN2CCNCC2)c(OC)c1OC
Molecular Formula
C14H22N2O3
Molecular Weight
266.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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