NLRP3 modulator 8

NLRP3 modulator 8 (Compound 14) is an NLRP3 regulator that can significantly degrade the NEK7 protein (DC50 = 9 nM) . In macrophages, NLRP3 modulator 8 can inhibit the activity of caspase-1 in a dose-dependent manner and reduce the release of IL-1β triggered by the activation of the NLRP3 inflammasome. NLRP3 modulator 8 is applicable for the research of various diseases, including autoinflammatory and autoimmune diseases, neurodegenerative diseases, as well as cardiovascular and metabolic-related diseases, etc.