NVP-QBE170
Product Specifications
CAS Number
1080018-61-6
Target
Sodium Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
NVP-QBE170 is a selective epithelial sodium channel (ENaC) inhibitor with an IC50 of 57.5 nM. It effectively suppresses ENaC function in human bronchial epithelial cells (HBEC), with a prolonged duration of action. NVP-QBE170 significantly decreases ENaC activity in guinea pig airway models and can be utilized for hyperkalemia research.
Smiles
O=C(NC(=N)NC1CCN(C(=O)C2=CC=C(C=C2)C(=O)N3CCC(NC(=N)NC(=O)C4=NC(Cl)=C(N=C4N)N)CC3)CC1)C5=NC(Cl)=C(N=C5N)N
Molecular Formula
C30H36Cl2N16O4
Molecular Weight
755.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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