PROTAC SGK3 degrader-2
Product Specifications
CAS Number
2381196-78-5
Target
PROTACs|||SGK
Related Pathways
Metabolism|||PROTAC
Bioactivity
PROTACSGK3degrader-2 is the cis-diastereomer of PROTACSGK3degrader-1 (SGK3-PROTAC1), featuring a cis-hydroxy group in its VH032 section, which prevents binding to the VHL E3 ligase. This compound inhibits SGK3, SGK1, and S6K1 with IC50 values of 0.6 ?M, 1.4 ?M, and 1.7 ?M, respectively, but does not degrade SGK3. It serves as a control compound for studying the specific degradation effects mediated by SGK3-PROTAC1.
Smiles
O(C[C@H]1CN(CCCCCCOCCOCCOCC(N[C@H](C(=O)N2[C@H](C(NCC3=CC=C(C=C3)C4=C(C)N=CS4)=O)C[C@H](O)C2)C(C)(C)C)=O)CCO1)C=5N=C(N=C6C5C=NN6)C7=CC=C(NS(=O)(=O)C8=C(F)C=CC(C)=C8)C=C7
Molecular Formula
C57H73FN10O11S2
Molecular Weight
1157.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/390881331343048822/T212560
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