PROTAC sEH-degrader-3
Product Specifications
CAS Number
3093413-94-3
Target
Epoxide Hydrolase, PROTACs
Related Pathways
Metabolism, PROTAC
Bioactivity
PROTACsEH-degrader-3 (Compound 1a) is a targeted sEH PROTAC degrader that selectively degrades cytosolic sEH without affecting sEH in peroxisomes. It degrades sEH through a CRBN-dependent lysosomal pathway rather than the proteasomal pathway, with an IC50 of 0.8 nM for hsEH. Additionally, PROTACsEH-degrader-3 inhibits endoplasmic reticulum stress, making it useful for research on diseases related to inflammation, metabolic disorders, and other conditions associated with endoplasmic reticulum stress.
Smiles
O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCOCCOCCOCCOCCNC(=O)C4=CC=C(O[C@H]5CC[C@H](NC(NC6=CC=C(OC(F)(F)F)C=C6)=O)CC5)C=C4)=O
Molecular Formula
C46H53F3N6O14
Molecular Weight
970.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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