ZWZH-21
Product Specifications
CAS Number
3069195-42-9
Target
Apoptosis, HDAC
Related Pathways
DNA Damage/DNA Repair, Chromatin/Epigenetic, Apoptosis
Bioactivity
WZH-21 is a selective and orally active dual HDAC1/2 inhibitor, exhibiting an IC50 of 34 nM for HDAC1 and 41 nM for HDAC2. It inhibits the growth of HCT116 and SW480 cells with IC50 values of 0.524 μM and 1.063 μM, respectively. WZH-21 suppresses proliferation and migration of various colorectal cancer cells and induces apoptosis (apoptosis) . It is applicable in cancer research, including studies on colorectal cancer.
Smiles
O=C(NC=1C=CC=CC1N)C2=CC=C(OCCN3C=4C=NC=CC4C=5C=CC=CC53)C=C2
Molecular Formula
C26H22N4O2
Molecular Weight
422.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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