LYA914
Product Specifications
Target
PROTACs, Androgen Receptor, Akt
Related Pathways
Endocrinology/Hormones, Cytoskeletal Signaling, PROTAC, PI3K/Akt/mTOR signaling
Bioactivity
LYA914 is an orally active AR/AR-V7 PROTAC degrader. It targets the proteolysis of the androgen receptor's (AR) conserved DNA-binding domain (DBD) . LYA914 demonstrates effective antiproliferative activity in Enzalutamide-insensitive or resistant cells and inhibits tumor growth in VCaP/LNCaP tumor mouse models. It is suitable for studying castration-resistant prostate cancer (CRPC) .
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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