LAB687
Product Specifications
CAS Number
256397-11-2
Target
MTP, Hedgehog/Smoothened, Smo
Related Pathways
Metabolism, Stem Cells, GPCR/G Protein
Bioactivity
LAB687 (Compound 2a) is an inhibitor of microsomal triglyceride transfer protein (MTP) with an IC50 of 0.9 nM for inhibiting the secretion of apolipoprotein B (apoB) in HepG2 cells. Additionally, LAB687 acts as a Smoothened (Smo) antagonist, exhibiting IC50 values of 2.48 μM and 3.42 μM for mouse and human Smo receptors, respectively. This compound is effective in reducing triglyceride and low-density lipoprotein cholesterol (LDL-C) levels and in inhibiting the Hedgehog signaling pathway.
Smiles
C(NC=1C=C2C(=CC1)C[C@@H](NC(OC)=O)C2)(=O)C3=C(C(C)=CC=C3)C4=CC=C(C(F)(F)F)C=C4
Molecular Formula
C26H23F3N2O3
Molecular Weight
468.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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