What is the catalog number for HIF-1α-IN-8?

The catalog number for HIF-1α-IN-8 is T212496.

What sizes are available for HIF-1α-IN-8?

HIF-1α-IN-8 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does HIF-1α-IN-8 come in?

HIF-1α-IN-8 is available in 2 different pack sizes.

Is HIF-1α-IN-8 in stock?

HIF-1α-IN-8 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures HIF-1α-IN-8?

HIF-1α-IN-8 is manufactured by Molfinity.

What is the estimated delivery time for HIF-1α-IN-8?

Estimated delivery time for HIF-1α-IN-8 is approximately 10 business day(s), depending on your location.

HIF-1α-IN-8

Product Specifications

Target

HIF/HIF Prolyl-Hydroxylase, IκB/IKK, Apoptosis, NF-κB, ROS

Related Pathways

NF-κB, Chromatin/Epigenetic, Metabolism, Apoptosis, Immunology/Inflammation

Bioactivity

HIF-1α-IN-8 is an orally active inhibitor of HIF-1α with an IC50 of 2.02 μM. It effectively suppresses the expression of inflammatory factors such as IL-6 and NO, reduces hypoxia-induced ROS production and apoptosis in C8-D1A cells, and inhibits the HIF-1α/IKKα/NF-κB signaling pathway. Additionally, it decreases the expression of proteins related to blood-brain barrier permeability. In a high-altitude cerebral edema (HACE) mouse model, HIF-1α-IN-8 lowers brain water content and oxidative stress levels. This compound is suitable for researching high-altitude cerebral edema (HACE) .