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PDGFRα kinase-IN-2

Product Specifications

CAS Number

3066103-58-7

Target

PDGFR

Related Pathways

Tyrosine Kinase/Adaptors, Angiogenesis

Bioactivity

PDGFRαkinase-IN-2 is a potent inhibitor of PDGFR-α with an IC50 of 2.1 nM. It exhibits anticancer activity against human colon cancer HT-29 cells, with an IC50 of 1.48 μM. Additionally, PDGFRαkinase-IN-2 demonstrates anti-angiogenic properties in zebrafish models with low embryotoxicity, making it suitable for research in colon cancer and anti-angiogenesis.

Smiles

O=C(NC1=CC=C(C=C1)NC=2N=CN=C3C=C(OC)C(OC)=CC32)NC4=CC=CC(=C4)C

Molecular Formula

C24H23N5O3

Molecular Weight

429.47

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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