H3R antagonist 6
Product Specifications
CAS Number
2183338-59-0
Target
Sigma receptor, Histamine Receptor
Related Pathways
Neuroscience, Immunology/Inflammation, GPCR/G Protein
Bioactivity
H3R antagonist 6 (Compounds 3) (H3-2406) is a histamine receptor 3 (H3R) antagonist with an IC50 of 5.6 nM. The 18F-labeled version exhibits high radiochemical yield, molar activity, and moderate brain uptake, although it shows off-target binding with the Sigma-1 receptor. It serves as a radioligand for positron emission tomography (PET) imaging in the study of central nervous system (CNS) diseases.
Smiles
O=C(N1CCN(CC1)C2CCCC2)C3CC3C4=CC=C(F)C=C4
Molecular Formula
C19H25FN2O
Molecular Weight
316.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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