SMI-10B13
Product Specifications
CAS Number
2502294-68-8
Target
Interleukin|||STAT
Related Pathways
Immunology/Inflammation|||Stem Cells|||JAK/STAT signaling
Bioactivity
SMI-10B13 is an inhibitor of oncostatin M (OSM) with a dissociation constant (KD) of 6.6 ?M. It effectively inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines, with IC50 values of 136 nM and 164 nM, respectively. SMI-10B13 demonstrates antitumor activity in a human breast cancer mouse model.
Smiles
O=C(O)C=CC=1OC(C=2C=CC=3C=CNC3C2)=C(C1)C=4C=CC=5C=CNC5C4
Molecular Formula
C23H16N2O3
Molecular Weight
368.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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