SCL-1
Product Specifications
CAS Number
1061105-16-5
Target
PD-1/PD-L1
Related Pathways
Cell Cycle/Checkpoint|||Immunology/Inflammation|||Apoptosis
Bioactivity
SCL-1 is an orally active anti-PD-1/PD-L1 inhibitor that disrupts the interaction between PD-1 and PD-L1. It enhances the numbers of T cells, B cells, and natural killer cells. SCL-1 exhibits potent tumor growth inhibitory effects by inducing effector T cells within the tumor and upregulating the expression of long non-coding RNAs as neoantigens, thereby activating cytotoxic T lymphocytes. SCL-1 is applicable in cancer research, including studies on triple-negative breast cancer.
Smiles
O=C(N1CCCCC1C)C2CCN(C3=NN4C(=NN=C4C(F)(F)F)C=C3)CC2
Molecular Formula
C18H23F3N6O
Molecular Weight
396.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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