FLT3-IN-32 hydrochloride
Product Specifications
CAS Number
3047195-66-1
Target
Akt, p38 MAPK, FLT, Apoptosis, STAT
Related Pathways
PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Stem Cells, MAPK, Angiogenesis, Apoptosis, JAK/STAT signaling
Bioactivity
FLT3-IN-32 hydrochloride is a potent, orally active FLT3 inhibitor with IC50 values of 0.29 nM for FLT3-ITD, 0.77 nM for FLT3-D835Y, and 2.07 nM for FLT3-N676K. It induces apoptosis in FLT3-mutant Ba/F3 cells by reducing the phosphorylation of FLT3 and its downstream signaling molecules (STAT5, MAPK, AKT) . In MV4-11 xenograft models, it demonstrates significant antitumor effects. This compound is suitable for research in acute myeloid leukemia (AML) .
Smiles
Cl.O=C(NC1=NOC(=C1)C(C)(C)C)NC=2C=CC=3OC(=CC3C2)C(=O)C4=CC=5C(=CC=C(O)C5CN(C)C)N4
Molecular Formula
C28H30ClN5O5
Molecular Weight
552.02
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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