K-833
Product Specifications
CAS Number
2639936-77-7
Target
GPCR
Related Pathways
GPCR/G Protein, Endocrinology/Hormones
Bioactivity
K-833 is a GPR119 agonist with EC50 values of 39.8 nM, 100 nM, 75.4 nM, and 12.6 nM for human, mouse, rat, and dog respectively. In acute intestinal peptide secretion in mice, K-833 modestly increases the secretion of glucagon-like peptide-1 (GLP-1) and, when used in combination with AM-5262, can synergistically enhance GLP-1 levels. K-833 is applicable in weight loss research.
Smiles
C(CC1=C(F)C=C(OCCCC2CCN(CC2)C=3N=CC(Cl)=CN3)C=C1)(=O)N4CC(CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)C4
Molecular Formula
C30H43ClFN5O7
Molecular Weight
640.14
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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