PNR-3-80
Product Specifications
CAS Number
1424353-63-8
Target
Endonuclease
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
PNR-3-80 is a selective inhibitor of apoptotic endonuclease G (EndoG), with an IC50 of 0.67 ?M, showing greater inhibition than against DNase I. It exhibits no inhibitory activity against DNase II, RNase A, proteases, lactate dehydrogenase, and superoxide dismutase 1. PNR-3-80 effectively protects human prostate cancer cells from cell death induced by Cisplatin and Docetaxel and inhibits DNA damage and autophagy (autophagy) prompted by Etoposide. This compound is applicable in studies of cellular damage.
Smiles
O=C1NC(=S)NC(=O)C1=CC2=CN(C(=O)C=3C=CC=4C=CC=CC4C3)C=5C=CC(Cl)=CC25
Molecular Formula
C24H14ClN3O3S
Molecular Weight
459.9
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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