Arf1-GEFs-IN-1
Product Specifications
CAS Number
3091068-95-7
Target
GTPase
Related Pathways
GPCR/G Protein
Bioactivity
Arf1-GEFs-IN-1 is a potent and orally active inhibitor of ADP-ribosylation factor 1-guanine nucleotide exchange factors (Arf1-GEFs), exhibiting an IC50 value of 40 μM in CT26 cells. Primarily, Arf1-GEFs-IN-1 induces tumor regression by triggering anti-tumor immune responses rather than direct cytotoxicity. It effectively enhances CCL5 expression and demonstrates excellent in vivo efficacy. Arf1-GEFs-IN-1 is applicable in colon cancer research.
Smiles
N(/N=C/C=1C=C2C(=CC1)NC=C2)C3=C4C5=C(SC4=NC=N3)CN(C)CC5
Molecular Formula
C19H18N6S
Molecular Weight
362.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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