VNT-101
Product Specifications
CAS Number
2894060-67-2
Target
Influenza Virus
Related Pathways
Microbiology/Virology
Bioactivity
VNT-101 is an orally active inhibitor of influenza A virus (IAV) . It disrupts NP-NP protein interactions, preventing NP oligomerization and destabilizing the viral ribonucleoprotein (RNP) complex, showing potent antiviral activity against multiple influenza A virus subtypes. In cell-based cytopathic effect (CPE) assays, VNT-101 has an EC50 value of 4-5 nM, while it measures 4-8 nM in neuraminidase (NA) assays and 21-45 nM in ribonucleoprotein (RNP) assays. Demonstrating strong in vivo antiviral efficacy, VNT-101 protects against lethal H1N1 virus infection in mice. VNT-101 is applicable to influenza A virus infection research.
Smiles
C(F)(F)(F)C1=C(C=C(C(N)=O)C(=O)N1)C2=CC=C(OC[C@H]3O[C@](COC)(C)COC3)C=C2
Molecular Formula
C21H23F3N2O6
Molecular Weight
456.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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