MA191
Product Specifications
Target
HSP, Apoptosis, PROTACs, FLT, Akt, ERK, STAT
Related Pathways
Tyrosine Kinase/Adaptors, Metabolism, Apoptosis, PROTAC, Angiogenesis, MAPK, JAK/STAT signaling, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Stem Cells
Bioactivity
MA191 is an FLT3 PROTAC degrader that effectively addresses FLT3 inhibitor resistance caused by the rebound activation of mitogen-activated kinases. It rapidly degrades FLT3-ITD via a mechanism involving VHL, Neddylation, and BIM, reducing FLT3-ITD levels prior to inducing apoptosis. Moreover, MA191 inhibits the proliferation of AML cells in zebrafish and is applicable for acute myeloid leukemia (AML) research.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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