JAK1-IN-17
Product Specifications
CAS Number
1315490-71-1
Target
JAK
Related Pathways
Stem Cells, JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic
Bioactivity
JAK1-IN-17 (Compound 31) is a highly selective JAK1 inhibitor with a Ki of 1.9 nM. It exhibits low whole blood migration, allowing it to maintain effective pharmacological activity in whole blood. JAK1-IN-17 is also a nitrile-containing compound that provides stable but weak reversible inhibition of CYP3A4 using a midazolam probe (IC50= 7.9 μM) . This compound is applicable in cancer research.
Smiles
[C@H](C)(O)C=1N(C2=C3C(NC=C2N1)=NC=C3)[C@@H]4CC[C@@H](C#N)CC4
Molecular Formula
C17H19N5O
Molecular Weight
309.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![PE/Cyanine5.5 Anti-Human CD11b Antibody[ICRF44]](https://cdn.genprice.uk/products/763/68dd14a9061270361e7d2515/imageurl/e-ab-f1146i.webp)
E-AB-F1146I-01 20 Tests
PE/Cyanine5.5 Anti-Human CD11b Antibody[ICRF44]
Sign In for Pricing
View Details E-AB-F1146I-02 100 Tests
PE/Cyanine5.5 Anti-Human CD11b Antibody[ICRF44]
Sign In for Pricing
View Details E-AB-F1146I-03 2x 100 Tests
PE/Cyanine5.5 Anti-Human CD11b Antibody[ICRF44]
Sign In for Pricing
View Details 
