What is the catalog number for Enpp-1-IN-27?

The catalog number for Enpp-1-IN-27 is T212339.

What sizes are available for Enpp-1-IN-27?

Enpp-1-IN-27 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does Enpp-1-IN-27 come in?

Enpp-1-IN-27 is available in 2 different pack sizes.

Is Enpp-1-IN-27 in stock?

Enpp-1-IN-27 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Enpp-1-IN-27?

Enpp-1-IN-27 is manufactured by Molfinity.

What is the estimated delivery time for Enpp-1-IN-27?

Estimated delivery time for Enpp-1-IN-27 is approximately 10 business day(s), depending on your location.

Enpp-1-IN-27

Product Specifications

Target

STING, PDE

Related Pathways

Metabolism, Immunology/Inflammation

Bioactivity

Enpp-1-IN-27 is a selective ENPP1 inhibitor with an IC50 of 14.68 nM, exhibiting approximately 410-fold selectivity over ENPP2 and roughly 10-fold selectivity over ENPP3. This compound stabilizes cGAMP levels and activates the STING pathway, leading to cytokine release and an enhanced innate immune response. In addition, Enpp-1-IN-27 activates ISRE and boosts cGAMP-mediated immune responses, demonstrating significant antitumor effects in 4T1 and CT26 syngeneic mouse models. It is applicable to breast cancer and colon cancer research.