PROTAC Bcl-xL degrader-4
Product Specifications
CAS Number
2930759-37-6
Target
Mitochondrial Metabolism|||ROS|||JNK|||ERK|||PROTACs|||Apoptosis|||Bcl-2 Family|||p38 MAPK
Related Pathways
Immunology/Inflammation|||Apoptosis|||Metabolism|||PROTAC|||MAPK
Bioactivity
PROTACBcl-xL degrader-4 (Compound 2-38-III) is a Bcl-xL PROTAC degrader with significant antitumor activity against HepG2 and HUVEC cells. It induces apoptosis by reducing mitochondrial membrane potential and activating the MAPK signaling pathway. PROTACBcl-xL degrader-4 markedly inhibits tumor growth in xenograft mouse models.
Smiles
O=C(OCCOCCOCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C5NC(=CC(=O)C5=C4)C=6C=CC=C7C=CC=CC76
Molecular Formula
C39H34N4O9
Molecular Weight
702.71
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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