Tuspetinib dihydrochloride
Product Specifications
CAS Number
3037216-20-6
Target
Apoptosis, FLT
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Apoptosis
Bioactivity
Tuspetinib (HM43239) dihydrochloride is a selective FLT3 inhibitor with oral bioactivity, exhibiting IC50 values of 1.1 nM for FLT3 wild type, 1.8 nM for FLT3ITD mutant type, and 1.0 nM for FLT3D835Y mutant type. As a reversible type I inhibitor, it directly suppresses FLT3 kinase activity and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib dihydrochloride inhibits the proliferation of leukemia cells and induces apoptosis (apoptosis) .
Smiles
ClC1=CN=C(NC2=CC(C3CC3)=CC(CN4C[C@H](N[C@H](C4)C)C)=C2)N=C1C5=CNC6=CC(C)=CC=C56.Cl.Cl
Molecular Formula
C29H35Cl3N6
Molecular Weight
573.99
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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